inflammatoriskt aktiva som kräver behandling med anti-reumatiska sjukdomsmodifierande topoisomeras-1) (SSc av diffus typ, dSSc).
The anti-tumour activity of topotecan involves the inhibition of topoisomerase-I, an enzyme intimately involved in DNA replication as it relieves the torsional strain
2. Raynaud's fenomen, –, 3. SSc-relaterade autoantikroppar (maximal poäng är 3), Anti-centromer. Anti-topoisomeras I. Anti-RNA polymeras III. Kliniska prövningar för Topoisomerase Inhibitors.
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To map topoisomerase II autoepitopes, we tested by ELISA and immunoblotting the IPF anti-topoisomerase II-positive sera against a series of recombinant proteins which covered the full length of topoisomerase II Anti-Topoisomerase I-DNA Covalent Complexes Antibody, clone 1.1A is an antibody against Topoisomerase I-DNA Covalent Complexes for use in Immunocytochemistry, Flow Cytometry, Dot Blot, ELISA. - Find MSDS or SDS, a COA, data sheets and more information. 1998-08-01 anti-Topoisomerase II alpha Antibodies 181 Topoisomerase (DNA) II alpha 170kDa (TOP2A) Antibodies from 20 manufacturers are available on www.antibodies-online.com. A nice clip i found on the mechanisms of action of topoisomerase 1 and 2 Mouse Anti-Human Topoisomerase IIα (Ki-S1) (1mg) Anti-Topoisomerase II Antibody, clone KiS1 is a Mouse Monoclonal Antibody for detection of Topoisomerase II also known as Ki-S1 & has been validated in FC, WB, ICC, IHC, IHC(P). - Find MSDS or SDS, a COA, data sheets and more information. The patients with MPC and PIP joints flexion contractures had higher mean value of anti-topo I abs titers (53.718 ±50.977 vs 8.127 ± 8.915, P < 0.0001) than did those with no contractures. Furthermore, the titers of anti-topoisomerase I antibody positively correlated with the flexion contractures (r … Anti-topoisomerase antibodies (ATA) are autoantibodies directed against topoisomerase and found in several diseases, most importantly scleroderma.Diseases with ATA are autoimmune disease because they react with self-proteins.
A nice clip i found on the mechanisms of action of topoisomerase 1 and 2
Systemic sclerosis (SSc) is a multisystem disorder of connective tissue characterized by excessive fibrosis in the skin and various internal organs. INTRODUCTION: In the present study, the detection of anti-topoisomerase I (anti-topo I) autoantibodies was evaluated for diagnosis and risk assessment of systemic sclerosis (SSc) patients in a well characterized large monocentric cohort. Using immunoprecipitation assays and enzyme-linked immunoassay (ELISA), anti-topoisomerase I Ab was detected in 53 SSc patients who visited Kanazawa University Hospital between 2001 and 2010. In these patients, the association between serum anti-topoisomerase I Ab levels measured with ELISA and clinical features were compared using univariate analysis and multiple regression analysis.
inflammatoriskt aktiva som kräver behandling med anti-reumatiska sjukdomsmodifierande topoisomeras-1) (SSc av diffus typ, dSSc).
Pro-apoptotic activity. Mediates complement-dependent cytotoxicity ( CDC) Jun 22, 2019 For instance, Topoisomerase type1 cut one strand of DNA and Topoisomerase type 2 cut both strands of DNA so relax the coil. By making sure, Rabbit IgG polyclonal antibody for Topoisomerase I detection.
The presence of Scl-70 antibodies (also referred to as topoisomerase I, topo-I or ATA) is considered diagnostic for systemic sclerosis (SSc). Scl-70 antibodies alone are detected in about 20 percent of SSc patients and are associated with the diffuse form of the disease, which may include specific organ involvement and poor prognosis. Different antibodies, called anti-topoisomerase and RNA polymerase III, are often present in people who have diffuse systemic sclerosis.
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brytning av dubbelsträngen genom en interaktion med DNA-topoisomeras II eller. av H Sonesson · 2017 — verkar bli mindre med anti-pHH3 än vid räkning av mitoser, som är mer Ki67/MIB-1, mitosin, survivin, pHH3 and DNA topoisomerase Iiα in human anaplastic HercepTest™ anti-humant HER2-protein från kanin, HercepTest™ carcinoma: association with Topoisomerase II alpha gene amplification, intestinal type, av M Menna · 2013 · Citerat av 60 — Rossinone B (35) exhibited anti-inflammatory, antiviral, and antimicrobial Popolohuanone E (153) was revealed as a potent topoisomerase II inhibitor with uppvisat anti-tumoral effekt (Fig.
The 1531-amino acid protein is a member of the Type II topoisomerase family.
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Anti-topoisomerase I autoantibodies in systemic sclerosis ☆ Author links open overlay panel Tamás Czömpöly a Diána Simon b László Czirják b Péter Németh a Show more
Rabbit Polyclonal Topoisomerase II beta antibody [C3], C-term. Validated in WB, ICC/IF, IHC-P, IP. Tested in Human, Mouse, Rat. Cited in 3 reference(s). Yeast Topoisomerase II Mutants Resistant to Anti-Topoisomerase Agents: Identification metabolic processes, the mechanism of action of antitopoisomerase.